NAD+ longevity molecule beginner's guide cellular illustration
NAD+ · Beginner Guide

What Is NAD+? A Beginner's Guide to the Longevity Molecule

VL
By VLA Editorial Team
Editorial
· Feb 14, 2026
· 5 min read

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell of your body. It powers mitochondrial energy production and activates sirtuins, proteins involved in cellular repair and longevity signalling.

Mitochondrial energy production powered by NAD+ in cellular respiration

Why It Declines

NAD+ levels fall roughly 50% between ages 40 and 60. Causes include increased consumption by DNA-repair enzymes (PARPs) and decreased biosynthesis.

Supporting Healthy NAD+

How To Support It

Precursors (NMN, NR), exercise, fasting, and quality sleep all support NAD+ pathways.

Ready to act on this? Read our Best NAD+ Supplements buying guide.

VL
Verified Longevity Advisor Editorial Team
Plain-English science writing. We read the studies so you don't have to.

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