Peer-Reviewed Sources

Research Library

A curated index of peer-reviewed longevity research, written for technical readers but accessible to anyone willing to follow the science.

NAD+ Pathways Mitochondria Autophagy Senescence
Featured research paper on cellular longevity and NAD+ metabolism Featured Paper
Cellular Longevity · 2024

NAD+ Decline in Aging and Its Pharmacological Rescue

A high-level overview of how NAD+ pathways shift with age, why precursor supplementation has become the most-studied direct longevity intervention, and where the evidence is still uncertain.

Read summary → Beginner's guide
All Research Summaries

Browse the library

Methylene blue and mitochondrial bioenergetics research summary Mitochondria

Methylene Blue and Mitochondrial Bioenergetics

How methylene blue acts as an alternative electron carrier in impaired respiratory chains.

3 Citations· Mar 2026
NAD+ decline with age and pharmacological rescue research NAD+

NAD+ Decline With Age

Why NAD+ levels drop ~50% between ages 40 and 60, and the role of PARPs.

Pathway Review
Comparative review of NMN and NR human clinical trial data Clinical

NMN vs NR: Human Trial Evidence

What recent human pharmacokinetic and safety studies say about both NAD+ precursors.

Comparative
At A Glance

The longevity hallmarks we cover

Twelve canonical hallmarks of aging guide how we organize the research library.

Hallmark 01

Genomic Instability

DNA damage accumulation and PARP-mediated NAD+ consumption.

Hallmark 02

Mitochondrial Dysfunction

Electron transport chain decline and alternative carriers.

Hallmark 03

Cellular Senescence

Senescent-cell accumulation and senolytic interventions.

Hallmark 04

Loss of Proteostasis

Autophagy, chaperone function, and protein-quality control.